Evaluate the accuracy of a profile-based predictor as a function of the max cosine similarity between training and test profiles.
Motivation: Protein Structural Annotations are essential abstractions to deal with the prediction of Protein Structures. Many increasingly sophisticated Protein Structural Annotations have been devised in the last few decades. However the need for …
Protein Structure Prediction is a central topic in Structural Bioinformatics. Since the ’60s statistical methods, followed by increasingly complex Machine Learning and recently Deep Learning methods, have been employed to predict protein structural …
State-of-the-art ab initio prediction of 1D protein structure annotations
Predicting the three-dimensional structure of proteins is a long-standing challenge of computational biology, as the structure (or lack of a rigid structure) is well known to determine a protein’s function. Predicting relative solvent accessibility …
This chapter aims to introduce to the specifics of protein structure annotations and their fundamental position in structural bioinformatics, bioinformatics in general. Proteins are profoundly characterised by their structure in every aspect of their …